01 - Heat the oven to 300°F.
02 - Combine kosher salt, black pepper, smoked paprika, brown sugar, garlic powder, onion powder, ground cumin, and chili powder in a small bowl to form a dry rub.
03 - Pat the brisket dry and apply the spice rub evenly over all sides.
04 - Place the sliced onions, smashed garlic, and sliced carrots in a large roasting pan or Dutch oven. Set the brisket on top, fat side up.
05 - Mix beef broth, red wine if using, and Worcestershire sauce. Pour around the brisket without covering it.
06 - Seal the pan tightly with aluminum foil or a lid and roast in the oven for 4 to 4½ hours until fork-tender.
07 - Remove from oven and let rest covered for 20 minutes to retain juices.
08 - Slice brisket against the grain and serve alongside the cooked vegetables and pan juices.